• Participants are between the ages of 14 -65 years of age

• Refractory to anti-seizure medications (ASMs).

• Persistence of disabling seizures at least 3 times per 3 months or greater, and once or more in recent 1 month.

• After comprehensive preoperative evaluation, patients who are considered unsuitable for or refuse resection surgery, or those for whom the effects of epileptic focus resection and thermocoagulation surgery are not satisfactory.

• Participants must have had a non-invasive video-EEG monitoring revealing seizure semiology and ictal EEG consistent with bilateral Temporal Lobe Epilepsy

• Biliteral hippocampal atrophy on MRI T1 imaging with increased ipsilateral mesial signal on T2 imaging

• Informed consent signed.